Microbiome Research

Metabolomics comprehensively characterizes small polar and lipid metabolites that are uniquely from bacterial processing or shared with the host and modified within the microenvironment of the microbiota. This facilitates the understanding of metabolites and their biological implications in host-microbiota interactions, including their involvement in a multitude of complex diseases, such as cardiovascular disease, metabolic syndromes, and obesity. Furthermore, their involvement in various aspects of these diseases can provide more insights on how to improve current precision medicine approaches, including personalized dietary interventions.

  • Request for Quote        More Info  
  • Introduction

    HMT’s metabolome analysis employs CE-MS & LC-MS platforms. Our technologies are optimized to measure small polar metabolites (including short chain fatty acids, modified indoles, polyamines, etc.), and dipeptides, in many types of samples, from sweat, tears to blood and fecal matter.

    Over 100 polar metabolites, many of which can be altered by the microbiome, are quantifiable with single- or multi-point calibration.

    High resolution
    Good separation of structural isomers, e.g. isobaric fatty acids, oxidative products.


    Examples of samples that can be analyzed at HMT

    Biofluids (serum, plasma, CSF, saliva, pleural fluid, etc.)
    biomarkers & diagnostic markers relating to disease severity, stress, inflammation
    monitor disease progression &/or drug response

    Urine, feces, cecal contents
    pathogen-induced dysbiosis
    detect inflammation-derived changes in metabolic profiles

    Cultured cells
    changes in energy metabolism in infected cells
    assessment of novel therapeutics

    Tissues from target organs
    interactions between specific tissues & pathogens
    monitor metabolic changes for enhanced evaluation of disease progression

    For overview of analysis services, click on more info