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Quantifying antibody-mediated neutralization of SARS-CoV-2 directly in serum

New Scientific Publication
The emergence of mutant variants of SARS-CoV-2 and associated concerns about the effects of these mutations on the efficacy of vaccines and therapeutics has underscored the vital importance of understanding the antibody response to SARS-CoV-2.

In our recent paper “In vitro measurements of protein–protein interactions show that antibody affinity governs the inhibition of SARS-CoV-2 spike/ACE2 binding in convalescent serum” we showcase the unique capabilities of our Fluidity One-W Serum platform and describe:

  • A new type of in-solution receptor-binding competition assay that quantifies the affinity, concentration, and neutralization potential of antibodies against the SARS-CoV-2 spike protein.
  • The ability of this platform to accurately and quantitatively profile the underlying protein interactions directly in serum.
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