Xenografting of Breast Cancer Cells using VitroGel System
RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.
In this research highlight, a joint team of researchers from Korean and Japanese cancer institutes performed a series of in vitro and in vivo experiments to investigate the expression and mode of action of the ring-finger protein RFN208. VitroGel, a xeno-free injectable hydrogel system was used for xenografting of triple-negative breast cancer cells into mice to help cell retention and test tumor growth in response to the upregulation of a ubiquitin-related ligase protein. The results show that RNF208 expression is closely associated with Vimentin-mediated aggressive cancer progression of breast cancer cells.