Join Us for ibiTea Webinar - Scientific Talk on Pancreas-Derived Organoids
Join ibidi on their 8th ibiTea webinar, with speaker Samuel Randriamanantsoa. Samuel will talk about the tremendous potential of organoids as in vitro platforms for studying the developmental dynamics of both healthy and cancerous tissues.
Topics discussed include:
How to use organoids in cancer research?
How to achieve complex organoid structures, and why this is important
How to perform live cell imaging and microscopy of 3D cell aggregates?
During research into pancreatic ductal adenocarcinoma (PDAC), a highly lethal disease, spheroid cultures yielded insight into the fundamental biological aspects of the tumors. However, these spheroid cultures did not morphologically match the complex structures observed in vivo.
Therefore, the researchers generated organoids from a single primary murine PDAC cell embedded in a collagen matrix.
These organoids self-organized into highly branched structures displaying a seamless lumen that connected terminal end buds, thus replicating in vivo PDAC architecture.
Samuel will present how they identified distinct morphogenesis phases and their dynamics through live imaging, chemical perturbations, sequencing, and biophysical modeling.
PDAC organoid, generated from a single primary tumor cell (nuclei, white), invades the surrounding collagen, and branches out.
Technische Universität München, Germany
Samuel studied engineering and biophysics at Télécom Physique and the University of Strasbourg in France. In 2019, he joined the laboratory of Prof. Andreas Bausch at the Technische Universität München as a PhD candidate investigating the spatiotemporal development dynamics of organoids. His main research interests are in the self-organization processes of living systems.