Metabolomics in Metabolic Disease Research

Metabolomics comprehensively characterizes small polar and lipid metabolites, yielding a snapshot of physiological processes that vary according to the pathological state of cells, tissues, and organs. Therefore, metabolomics profiling can help to reveal specific metabolic changes, for example, aberrant levels of amines, amino acids, and lipids, that are known to associate with many metabolic diseases, such as obesity, diabetes, and cardiovascular diseases. Furthermore, metabolomics has a great potential for identifying biomarkers, as well as predictive and risk markers that are associated with disease development and progression, thus, providing an effective strategy for novel therapeutic innovations.

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  • Introduction

    HMT’s metabolome analysis employs CE-MS & LC-MS platforms. Our technologies are optimized to measure small polar metabolites that are involved in a myriad of metabolic diseases, e.g., amino acids, short-chain fatty acids, polyamines in most types of samples, including blood, tissues, and cultured cells.

    Over 100 polar metabolites involved in metabolic diseases can be quantified with single- or multi-point calibration.

    High resolution
    Good separation of structural isomers, e.g. isobaric fatty acids, oxidative products.


    Examples of samples that can be analyzed at HMT

    Biofluids (serum, plasma, CSF, saliva, pleural fluid, etc.)
    biomarkers & diagnostic markers relating to disease severity, stress, inflammation
    monitor disease progression &/or drug response

    Urine, feces, cecal contents
    pathogen-induced dysbiosis
    detect inflammation-derived changes in metabolic profiles

    Cultured cells
    changes in energy metabolism in infected cells
    assessment of novel therapeutics

    Tissues from target organs
    interactions between specific tissues & pathogens
    monitor metabolic changes for enhanced evaluation of disease progression

    For overview of analysis services, click on more info