Metabolomics in Infectious Disease Research

Metabolomics comprehensively characterizes small polar and lipid metabolites, yielding a snapshot of physiological processes that vary according to the pathological state of cells, tissues, and organs. Therefore, the use of metabolomics can help to reveal specific metabolic alterations and potential biomarkers that are associated with disease severity in patients with systemic infections. Furthermore, metabolomics has a great potential for exploring predictive and risk markers of disease development. This will contribute immensely to the treatment and prevention of infectious diseases.

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Introduction

HMT’s metabolome analysis employs CE-MS & LC-MS platforms. Our technologies are optimized to measure metabolites related to cellular energy metabolism, e.g., amino acids, short-chain fatty acids, polyamines in most types of samples, including serum, plasma, tissues, fecal matter, cells, animal models and clinical specimens.

Quantitation
Over 100 polar metabolites, many of which can be altered in pathogenic infections, are quantifiable with single- or multi-point calibration.

High resolution
Good separation of structural isomers, e.g. isobaric fatty acids, oxidative products.

Description

Examples of samples that can be analyzed at HMT

Biofluids (serum, plasma, CSF, saliva, pleural fluid, etc.)
biomarkers & diagnostic markers relating to disease severity, stress, inflammation
monitor disease progression &/or drug response

Urine, feces, cecal contents
pathogen-induced dysbiosis
detect inflammation-derived changes in metabolic profiles

Cultured cells
changes in energy metabolism in infected cells
assessment of novel therapeutics

Tissues from target organs
interactions between specific tissues & pathogens
monitor metabolic changes for enhanced evaluation of disease progression

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