Metabolomics in Infectious Disease Research

Metabolomics comprehensively characterizes small polar and lipid metabolites, yielding a snapshot of physiological processes that vary according to the pathological state of cells, tissues, and organs. Therefore, the use of metabolomics can help to reveal specific metabolic alterations and potential biomarkers that are associated with disease severity in patients with systemic infections. Furthermore, metabolomics has a great potential for exploring predictive and risk markers of disease development. This will contribute immensely to the treatment and prevention of infectious diseases.

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  • Introduction

    HMT’s metabolome analysis employs CE-MS & LC-MS platforms. Our technologies are optimized to measure metabolites related to cellular energy metabolism, e.g., amino acids, short-chain fatty acids, polyamines in most types of samples, including serum, plasma, tissues, fecal matter, cells, animal models and clinical specimens.

    Over 100 polar metabolites, many of which can be altered in pathogenic infections, are quantifiable with single- or multi-point calibration.

    High resolution
    Good separation of structural isomers, e.g. isobaric fatty acids, oxidative products.


    Examples of samples that can be analyzed at HMT

    Biofluids (serum, plasma, CSF, saliva, pleural fluid, etc.)
    biomarkers & diagnostic markers relating to disease severity, stress, inflammation
    monitor disease progression &/or drug response

    Urine, feces, cecal contents
    pathogen-induced dysbiosis
    detect inflammation-derived changes in metabolic profiles

    Cultured cells
    changes in energy metabolism in infected cells
    assessment of novel therapeutics

    Tissues from target organs
    interactions between specific tissues & pathogens
    monitor metabolic changes for enhanced evaluation of disease progression

    For overview of analysis services, click on more info