Maurice

Maurice innovates the conventional capillary electrophoresis technology to automate your protein profiling either by size or charge. Need cIEF and CE-SDS data for your mAbs, ADCs, vaccines or virus-like particles? Maurice does it all. Just pop in one of the preassembled cartridges, drop in your sample vials or a 96-well plate, and hit start. You will complete method development in a day; and get high-resolution, reproducible data in minutes.

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    Maurice affords high-resolution characterization of charge variants by preserving our proprietary imaged capillary isoelectric focusing (icIEF) technology, which has been the go-to method for measuring charge heterogeneity. The whole-column detection eliminates the post-focusing mobilization step needed with traditional cIEF, and can resolve your most challenging molecules including fusion proteins and hydrophobic ADCs.

    Mô Tả

    ATUREcIEF SPECIFICATIONCE-SDS SPECIFICATION
    Minimum Sample Volume50 µL50 µL
    Sample DeliveryVacuumElectrokinetic
    Typical Separation Time6–10 min (molecule-dependent)Reduced IgG: 25 min,
    Non-reduced IgG: 35 min
    Detection CapabilityUV Absorbance at 280 nm
    Fluorescence: Ex 280 nm, Em 320–450 nm
    UV Absorbance at 220 nm
    Typical VoltagePre-focusing: 1500 V, focusing: 3000 VSeparation: 5750 V
    Sample Injections per Cartridge100 guaranteed, 200 maximum100 guaranteed, 200 maximum
    Maximum Sample Injections per Batch10048
    pI/Size Range2.85–10.4510–270 kDa
    pI/Sizing CV1%≤2%
    CV for Peaks >10% Composition≤5% (Intra-batch), ≤6% (Inter-batch)N/A
    Relative Migration Time CVN/A<1% for reduced IgG
    pI/Sizing Resolution0.05 pI units (for wide range 3–10 ampholytes)≥1.5 for NGHC/HC IgG Standard
    Dynamic Range2 logs2 logs
    Linearity>0.995>0.995
    Sensitivity (LOD)0.7 µg/mL (Native fluorescence)
    3.0 µg/mL (Absorbance)
    (Values based on a monoclonal antibody)
    0.3 µg/mL
    (Value based on Internal Standard)
    Sample Tray Options96-well plates or 48 vials
    Dimensions44cm H x 42cm W x 61cm D
    Weight46 kg (100 lb)
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