μCollaFibR™ Additive for Bioinks and Hydrogels
3DBioFibR’s patented dry-spinning technology produces μCollaFibR™; 50 μm collagen fibers that increase the shape fidelity and biological relevance of bioprinted constructs.
3DBioFibR’s patented dry-spinning technology produces μCollaFibR™; 50 μm collagen fibers that increase the shape fidelity and biological relevance of bioprinted constructs.
3D Bioprinting is a promising approach for personalized tissue engineering, but the lack of mechanical durability and biological relevance of bioprinted constructs has limited their clinical viability. 3DBioFibR’s patented dry-spinning technology produces μCollaFibR™; 50 μm collagen fibers that increase the shape fidelity and biological relevance of bioprinted constructs. With excellent chemical stability and 1-2 μm diameters, μCollaFibR™ is universally compatible with bioprinting materials and modalities.
Produced using GMP type I collagen, and resembles the structure of natural collagen fibers
Can be resuspended in any aqueous environment, including acidic environments (pH≥2)
Increases mechanical strength and modulus of hydrogels in extension and compression
Improves shape retention/durability for at least 28 days in cellular constructs
Acts as a physiologically relevant site for cell attachment within the constructs, improving cellular viability and functionality
Improves shape fidelity without compromising bioink viscosity/printability
Compression: 5%., GelMA with 1.25 mg/mL CollaFibR™
Extension: 7.5%., GelMA with 2.5 mg/mL CollaFibR™
| Collagen | Bovine Type I |
| Length | 44 ± 13 μm |
| Diameter | 1 − 2 μm |
| **Stability in Solution | ≥ 3 months at pH 2 − 7.4 |
| Temperature Stability | ≤ 60 oC |
| Hydrated Young's Modulus | 50 ± 16 kPa |
| Storage | 4 oC short term, 20 oC long term |
| Degrading Enzyme | Collagenase I/IV |
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