Metabolomics comprehensively characterizes small polar and lipid metabolites, yielding a snapshot of physiological processes that vary according to the pathological state of the cell, tissue, organ, or organism. Therefore, the use of metabolomics can help to reveal specific metabolic changes, for example, alterations in the central carbon metabolism and signal transmissions, in the brain and in biofluids such as CSF and plasma. This will provide more insights on the pathogenesis of neurodegenerative (multiple sclerosis, Alzheimer’s and Parkinson’s diseases, etc.) and neuro-psychiatric diseases (schizophrenia, bipolar disorder, depression, etc.), thus uncovering potential diagnostics and biomarkers, both prior to onset and during disease progression.
HMT’s metabolome analysis employs CE-MS & LC-MS platforms. Our technologies are optimized to capture signaling metabolites, polyamines, energy metabolism in many types of samples, from brain and nervous tissues, biofluids, retina, to neuronal cells.
Over 100 polar metabolites, many of which are involved in neuronal signaling, can be quantified with single- or multi-point calibration.
Good separation of structural isomers, e.g. isobaric fatty acids, oxidative products.
Examples of samples that can be analyzed at HMT
Biofluids (serum, plasma, CSF, saliva, pleural fluid, etc.)
biomarkers & diagnostic markers relating to disease severity, stress, inflammation
monitor disease progression &/or drug response
Urine, feces, cecal contents
detect inflammation-derived changes in metabolic profiles
changes in energy metabolism in infected cells
assessment of novel therapeutics
Tissues from target organs
interactions between specific tissues & pathogens
monitor metabolic changes for enhanced evaluation of disease progression
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