Metabolomics in Cancer Research

Metabolomics comprehensively characterizes small polar and lipid metabolites, yielding a snapshot of physiological processes that vary according to the pathological state of cells, tissues, and organs. Therefore, metabolomics profiling can help to identify specific metabolic changes in cancer cells and tissues, providing a deeper understanding of the role altered cellular metabolism plays in tumorigenesis, as well as in disease progression. Furthermore, targeting cancer metabolism pathways with metabolomics will be useful in determining critical biomarkers for early detection and therapeutic interventions.

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  • Introduction

    HMT’s metabolome analysis employs CE-MS & LC-MS platforms. Our technologies are optimized to measure metabolites related to cellular energy metabolism, e.g., amino acids, short-chain fatty acids, polyamines, in most types of samples, including blood, tissues, and cultured cells.

    Over 100 polar metabolites involved in cancer metabolism are quantifiable with single- or multi-point calibration.

    High resolution
    Good separation of structural isomers, e.g. isobaric fatty acids, oxidative products.


    Examples of samples that can be analyzed at HMT

    Biofluids (serum, plasma, CSF, saliva, pleural fluid, etc.)
    biomarkers & diagnostic markers relating to disease severity, stress, inflammation
    monitor disease progression &/or drug response

    Urine, feces, cecal contents
    pathogen-induced dysbiosis
    detect inflammation-derived changes in metabolic profiles

    Cultured cells
    changes in energy metabolism in infected cells
    assessment of novel therapeutics

    Tissues from target organs
    interactions between specific tissues & pathogens
    monitor metabolic changes for enhanced evaluation of disease progression

    For overview of analysis services, click on more info