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Hound

Unchained Labs

Particles screw up the quality of your drug and can even shut down production. Hound is the only tool out there that combines microscopy, Raman and Laser-Induced Breakdown Spectroscopy (LIBS) to forensically identify particles by their chemical and elemental fingerprints. You’ll know the culprit without a doubt in minutes — so you can track it back to the source and fix it asap.

Gather the evidence

If you see particles or suspect they might be there, Hound sniffs them out. Just pour your whole sample through a filter round or pipette your particle onto a wet round, drop it in the Hound and you’re ready to go. Don’t sweat it — the gold-coated surfaces catch everything and cut out all the background noise.

Track down your leads

Once you’ve snagged all your particles, Hound automatically spots them and narrows down the list of suspects. It uses bright-field, dark-field and fluorescence so nothing sneaks by — not even those tricky translucent proteins. It scans the round then reports the size and shape of every particle, so you can make the call on which leads to follow.

Start the interrogation

Hound IDs the chemical makeup of protein and organic materials using Raman spectroscopy. Each particle gets fingerprinted and compared to a customizable reference database to make sure you get an exact match. You’ll know right off the bat if a particle is from protein aggregation, rubber from a bad stopper or something random that snuck in.

Rough them up

When your process hits a snafu like metal shedding from a fermenter or glass chipping off a vial into your drug, Hound has your back with Laser-Induced Breakdown Spectroscopy (LIBS). A laser blasts part of each inorganic or metal particle into smithereens. Their elements are released and checked against a reference library so you can ID the perp and crack the case.

Specifications

 DescriptionSpecification
MicroscopyImaging: 2 MP color camera, 10x, 20x (DF and BF), 50x objectives Illumination: Integrated bright-field and dark-field illumination Particle size range: 2 μm – 15 mm Accuracy: ±5% sizing (magnification dependent), ±15% counting
RamanLaser: Adjustable power, 50x, 0.55 NA, 5.0 mm WD 785 nm: ≤50 mW, 200–2000 cm-1, resolution 5 cm-1 532 nm: ≤20 mW, 200–3200 cm-1, resolution 5 cm-1 Minimum particle size: 2 μm Database: ~140 typical contaminants, expandable
LIBSLaser: Safety Class 1, Pulse-LASER w/130 μJ, 3 ns duration, 20 x UV lens Spectral range: 350–700 nm, resolution 1 nm Minimum particle size: 20 μm Database: 50 typical contaminants, expandable
 Filter roundsMaterial: Gold coated polycarbonate (PC) — 2 μm min. particle size Gold coated polytetrafluorethylene (PTFE) — 2 μm min. particle size pH range: 1–14
 Wet roundsMaterial: Gold or nickel coated Optical transmission: 255–850 nm
 Software21 CFR Part 11 & USP <788>, Method 2, ISO 8871-3:2004 compliance included
 EnvironmentalTemperature range: 15–30 °C Humidity: 0–95% relative humidity (non-condensing)
PhysicalTemperature range: 15–30 °C Humidity: 0–95% relative humidity (non-condensing)
Electrical110–230 V, 500 W