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Unchained Labs

The UNit lets you learn more about protein stability with less sample than any other tool out there. Up your knowledge base on your protein constructs and formulations.
Measure Tm and Tagg simultaneously in under two hours. Do it all on the most powerful biologics stability screening platform.

Get more data with way less protein. The UNi only needs 9 µL of sample, and you pick how you use it. Run 1 sample in the morning, 48 in the afternoon. Do a DLS read if that’s all you need. Or, check DLS, then start a 3-day experiment to monitor real-time stability. Your samples are sealed airtight, so runs can be short or long — your call.

Biologics behave differently. With UNcle, you get the whole fluorescence spectrum, so you don’t need to know ahead of time how your protein behaves. No need to add dyes either. UNcle picks up aggregation on two wavelengths — you’ll see both small and large aggregates no matter what.

Description Specification
Minimum sample volume 9 µL, sealed capillaries
Simultaneous samples per experiment 48
Protein concentration range 0.1 mg/mL–150 mg/mL IgG (protein dependent)
SLS resolution ~15 kDa change in mean molecular mass
Sample temperature range 15–95 °C
Heating rate 0.01–10 °C/minute
Sample Tm precision <2% CV (protein dependent)
Excitation Standard: 266 nm and 473 nm
Optional: 375 nm or 445 nm
Fluorescence detector Spectrometer: full 250–720 nm spectral range
Static light scattering detector Spectrometer: scatter intensity at 266 nm and 473 nm
Environmental conditions Temperature range: 18–28 °C
Humidity: 40–60% relative humidity (non-condensing)
Physical 54 cm W x 50 cm D x 58 cm H, 46 kg
Electrical Auto switching power supply, voltage 110–240 V AC, 50–60 Hz
Fuse rating 6 A anti-surge, max power 600 W